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TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Published in Nature Immunology, 2019
Tu, A. A., Gierahn, T. M., Monian, B., Morgan, D. M., Mehta, N. K., Ruiter, B., Shreffler, W. G., Shalek, A. K., Love, J. C. "TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures." Nature Immunology. 20, 1692-1699 (2019). https://doi.org/10.1038/s41590-019-0544-5
Clonally expanded, GPR15-expressing pathogenic effector Th2 cells are associated with eosinophilic esophagitis
Published in Science Immunology, 2021
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Focus: "Zooming in on T cell clones: Are we heading to personalized treatment of allergy?" by Netali Ben-Baruch Morgenstern, Mark Rochman, and Marc Rothenberg
Morgan, D. M., Ruiter, B., Smith, N. P., Tu, A. A., Monian, B., Stone, B. E., Virk-Hundal, N., Yuan, Q., Shreffler, W. G., Love, J. C. "Clonally expanded, GPR15-expressing pathogenic effector Th2 cells are associated with eosinophilic esophagitis." Science Immunology, 6, eabi5586 (2021). https://doi.org/10.1126/sciimmunol.abi5586
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer
Published in Science Immunology, 2021
Horton, B. L., Morgan, D. M., Momin, N., Zagorulya, M., Torres-Meija, E., Bhandakar, V., Wittrup, K. D., Love, J. C., Spranger, S. (2021). "Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer." Science Immunology. 6, abi8800 (2021). https://doi.org/10.1126/sciimmunol.abi8800
Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells
Published in The Journal of Clinical Investigation, 2022
Monian, B, Tu, A. A., Ruiter, B., Morgan, D. M., Petrossian, P. M., Smith, N. P., Gierahn, T., M., Ginder, J., Shreffler, W. G., Love, J. C. "Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells" The Journal of Clinical Investigation. 132(2):e150634 (2022). https://www.jci.org/articles/view/150634
WAT3R: Recovery of T-Cell Receptor Variable Regions from 3` Single-Cell RNA Sequencing.
Published in Bioinformatics, 2022
Ainciburu, M., Morgan, D. M., DePasquale, E. A. K., Love, J., C., Propser, F., van Galen, P. "WAT3R: Recovery of T-Cell Receptor Variable Regions from 3` Single-Cell RNA Sequencing." Bioinformatisc 8(14):3645-3647 (2022). https://academic.oup.com/bioinformatics/article/38/14/3645/6604269
Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations
Published in Nature Biotechnology, 2022
Miller, T. E., Lareau, C. A., Verga, J. A., DePasquale, E. A. K., Liu, V., Ssozi, D., Sandor, K., Yin, Y., Ludwig, L. S., El Farran, C. A., Morgan, D. M., Satpathy, A. T., Griffin, G. K., Lane, A. A., Love, J. C., Bernstein, B. E., Sankaran, V. G., van Galen, P. "Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations" Nature Biotechnology, 40, 1030-1034. (2022) https://www.nature.com/articles/s41587-022-01210-8
Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma
Published in Frontiers in Immunology, 2022
Grace, B. E., Backlund, C. M., Morgan, D. M., Kang, B. H., Singh, N. K., Huisman, B. D., Rappazzo, C. G., Mohnihan, K. D., Maiorino, L., Dobson, C. S., Kyung, T., Gordon, K. S., Holec, P. V., Takou Mbah, O. C., Garafola, D., Wu, S., Love, J. C., Wittrup, K. D., Irvine, D. J., Birnbaum, M. E., 'Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma.' Frontiers in Immunology, 13:886683 (2022). https://www.frontiersin.org/articles/10.3389/fimmu.2022.886683/full
Revealing the heterogeneity of CD4+ T cells through single-cell transcriptomics
Published in Journal of Allergy and Clinical Immunology, 2022
Morgan, D. M., Shreffler, W. G., Love, J. C. "Revealing the heterogeneity of CD4+ T cells through single-cell transcriptomics." Journal of Allergy and Clinical Immunology, 150, 748-55 (2022). https://doi.org/10.1016/j.jaci.2022.08.010
Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Published in Science, 2023
Aung, A., Cui, A., Maiorino, L., Soleimany, A. P., Gregory, J. R., Bukenya, M., Zhang, Y., Lee, H,. Cottrell, C. A., Morgan, D. M., Silva, M., Sug, H., Kirkpatrick, J. D., Amlashi, P., Remba, T., Froehle, L. M., Xiao, S., Abraham, W., Adams, J. A., Love, J. C., Huyett, P., Kwon, D. S., Hacohen, N., Schief, W. R., Bhatia, S. N., Irvine, D. J. "Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens." Science, 379, 6630, 332-333, (2023). https://doi.org/10.1126/science.abn8934
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Published in Immunity, 2023
Zagorulya, M., Yim, L., Morgan, D. M., Edwards, A., Torres-Mejia, E., Momin, N., McCreery, C. V., Zamora, I. L., Horton, B. L., Wittrup, K. D., Love, J. C., Spranger, S. "Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer." Immunity 56, 2, 386-405. e10 (2023). https://doi.org/10.1126/science.abn8934
Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to vaccination
Published in biorXiv, 2023
Morgan, D. M., Zhang, Y., Kim, J., Murillo, M., Loschko, J., Surendran, N., Patil, S. U., Kanevsky, I., Chorro, L., Love, J. C. “Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to vaccination”. In Review. https://www.biorxiv.org/content/10.1101/2023.05.23.541927v1.abstract
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Published in Cell, 2023
Ma, L., Hostetler, A.*, Morgan, D. M.*, Maiorino, L.*, Sulkaj, I., Yousefpour, P., Whittaker, C. A., Nesser, A., Pires, I. S., Yousefpour, P., Gregory, J., Qureshi, K., Dye, J., Abraham, W., Suh, H., Li, N., Love, J. C., Irvine, D. J. "Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity." Cell, 186, 1-18 (2023). *Equal contribution https://doi.org/10.1126/science.abn8934
Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death
Published in biorXiv, 2024
Lal, M., Burke, C. M., Gautam, R., Mrozek, Z., Trachsel, T., Beers, J., Carroll, M. C., Morgan, D. M., Muir, A. B., Shreffler, W. G., Ruffner, M. A. “Inteferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.” In Review. https://www.biorxiv.org/content/10.1101/2024.01.26.577407v1
Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells
Published in biorXiv, 2024
Ma, L., Ramasubramanian, R., Mehta, N. K., Cossette, B., Morgan, D. M., Sukaj, I., Bergaggio, E., Kadauke, S., Meyers, R. M., Paruzzo, L., Ghilardi, G., Grzywa, T. M., Cozzone, A., Schuster, S. J., Frey, N., Zhang, L., Yousefpour, P., Abraham, W., Suh, H., Ruella, M., Grupp, S. A., Chiarle, R., Wittrup, K. W., Irvine, D. J. "Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells." In Review. https://www.biorxiv.org/content/10.1101/2024.04.16.589780v2.abstract
Vaccines combining slow delivery and follicle targeting of antigens increase germinal center B cell clonal diversity and clonal expansion
Published in biorXiv, 2024
Rodrigues, K. A., Zhang, Y. J., Aung, A., Morgan, D. M., Maiorino, L., Yousefpour, P., Gibson, G., Ozorowski, G., Gregory, J. R., Amlashi, P., Buckley, M., Ward, A. B., Schief, W. R., Love, J. C., Irvine, D. J. “Vaccines combining slow delivery and follicle targeting of antigens increase germinal center B cell clonal diversity and clonal expansion. In Review. https://www.biorxiv.org/content/10.1101/2024.08.19.608655v1
Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen in response to immune checkpoint blockade
Published in Science Immunology, 2024
Morgan, D. M.*, Horton, B. L.*, Bhandarkar, V.*, Van, R., Dinter, T., Zagorulya, M., Love, J. C., Spranger, S. “Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen in response to immune checkpoint blockade.” Science Immunology, 9, 99 adi3487 (2024). *Equal Contribution https://www.science.org/doi/10.1126/sciimmunol.adi3487
talks
Utility of TCR Sequencing in Allergy
Published:
teaching
Teaching experience 1
Undergraduate course, University 1, Department, 2014
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Teaching experience 2
Workshop, University 1, Department, 2015
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